Nephrology and Renal Care

Pre-eclampsia and kidney disease

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Complications associated with pregnancy which is characterized by high blood pressure are called pre-eclampsia (toxemia). In general, there may be no symptoms but high blood pressure and protein loss in urine are key features in pre-eclampsia. Water retention and swelling of legs are common in pregnant women which make it harder to distinguish it as pre-eclampsia from a normal pregnancy. Women having kidney disease even with mild reductions are at risk of toxemia which might lead to acute kidney injury, endothelial damage, and podocyte loss. Chronic kidney disease may put risk to the development of preeclampsia due to comorbid conditions, such as hypertension, but is also connected with impaired glycocalyx integrity and alterations in the complement and renin-angiotensin-aldosterone systems. Pre-eclampsia is diagnosed before delivery but in some cases, it may begin in the period after delivery which is known as postpartum preeclampsia.

Related associations and societies:  American Society of Nephrology (ASN), UK Kidney Association (UKKA), Canadian Society of Nephrology (CSN), Hong Kong Society of Nephrology (HKSN), Saudi Society of Nephrology and Transplantation (SSN&T), Australian and New Zealand Society of Nephrology (ANZSN), American Society of Transplantation (AST), Malaysian Society of Nephrology (MSN), National Kidney Foundation (NKF), International Society of Nephrology (ISN), California Dialysis Council (CDC), International Society for Hemodialysis (ISHD)